Chemotherapy side effects

During cancer treatment, you may experience different side effects. These can vary depending on the type of cancer you have, the stage of your cancer and the kind of treatment you are undergoing.

Everyone will experience side effects uniquely. It’s important to discuss any side effects you have with your care team so they can help you manage them during your treatment.

While chemotherapy destroys cancer cells, it is the damage to healthy cells that causes many of the common side effects of chemotherapy. Side effects vary depending on the type of chemotherapy drug used and your own body and tolerance to treatment. Most are temporary and can be treated or managed. Some side effects include:

Nausea and vomiting

Feeling sick or queasy (nausea) and vomiting (throwing up) is a common problem for people being treated for cancer, however there are many things that can help your nausea and vomiting become well managed and controlled. After chemotherapy, some people develop nausea and vomiting within minutes or hours while others may develop symptoms two to three days later. The nausea and vomiting may last for up to 24 hours or in some cases can last up to seven days.

Loss of appetite and changes to tastebuds

A change in taste and smell is a common side effect during or following cancer treatment. Normal taste and smell usually returns two to three months after your treatment finishes. These changes can impact your appetite and as a consequence your food intake.


Cancer-related fatigue is the chronic, distressing, emotional and physical exhaustion that many people with cancer experience. For some, fatigue can be quite severe and may interfere with everyday life. However, everyone’s experience of fatigue is different and often depends on the type of cancer and treatment approach.

Diarrhoea or constipation

Diarrhoea refers to increased frequency and decreased consistency of bowel motions. Certain chemotherapy drugs are more likely to cause diarrhoea than others. Symptoms can range from mild to severe and generally last for several days after treatment.

Constipation refers to bowel motions that are too hard, too small, too difficult to expel and too infrequent.  There are a number of disease and treatment related factors which can cause constipation. If you’re experiencing constipation, you may pass bowel motions less frequently than usual; pass dry, hard stools and have to strain to open your bowels. You may also have abdominal pain, nausea and/or vomiting, abdominal distention and loss of appetite.

Mouth sores or ulcers

Mouth sores occur when the lining of the mouth is damaged following chemotherapy or localised radiotherapy. All chemotherapy drugs have the potential to cause mouth sores. Other factors which contribute to mouth sores include neutropenia (low white blood cell count), infections in the mouth/throat, poor oral hygiene and smoking.

Hair loss, skin changes, nail changes

Some chemotherapy drugs can cause hair loss ranging from complete to thinning or patchy loss. Hair loss can be very distressing. It’s important to remember that in most cases, hair will regrow after your treatment finishes. Chemotherapy induced hair loss commonly occurs approximately two to three weeks following the start of treatment.

It’s very common to develop skin and nail reactions as a result of your chemotherapy treatment. The majority of intravenous and oral chemotherapy can cause some mild to moderate skin reactions. You may experience dry skin, rash, photosensitivity, nail problems and hyper-pigmentation.


Cancer and the effects of treatments can increase your risk of infection. Neutropenia is when neutrophils, a type of white blood cell that helps fight infection, are low. The lower your neutrophil count drops the greater your risk of developing an infection and the harder it is for your body to deal with the infection on its own.

Bleeding or bruising

Low platelet counts can occur due to disease or can be side effects of chemotherapy. Thrombocytopenia refers to a reduction in the normal levels of functional platelets, which can increase your risk of bruising and bleeding.


Anaemia is defined as a reduced number of red blood cells in your body or a low haemoglobin level. Chemotherapy can cause anaemia by interfering with the body’s natural process of creating new blood cells within bone marrow. If you’re experiencing anaemia, you may feel run down and weak, appear pale, feel short of breath, tire easily or get light-headed when you stand up.


Sometimes cancer and its treatment can affect your fertility, such as your ability to conceive a child or maintain a pregnancy. Infertility can be very significant and distressing. At the time of diagnosis parenthood may not be your priority but steps can be taken to protect your fertility for the future. Regardless of your gender or sexual orientation, it’s your right to have a conversation with your care team about fertility and explore your options.


Lymphoedema is the swelling of a limb and/or parts of the body caused by the lymphatic system not functioning properly. The lymphatic system plays an important role in the body’s defence against infection by filtering and removing bacteria. The swelling can occur when the normal process of lymph drainage doesn’t work properly. This can affect certain parts of the body. For people with lymphoedema, you may have an unexplained swelling which increases over time, and can lead to a feeling of heaviness and discomfort in the area. If left untreated, it can lead to loss of mobility and the skin becoming prone to infection.

It is important to know that many patients do not experience these side effects. For those who do, the symptoms can often be well managed via medication.

If you experience unusual symptoms, it is important to consult your doctor or nurse. We encourage our patients to discuss any concerns you have so we can help you manage.

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